Journal
ORGANIC LETTERS
Volume 13, Issue 6, Pages 1498-1501Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol2001864
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Funding
- National Research Foundation of Korea [2010-0000728]
- MEST [20100001630]
- Sungkyunkwan University
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A new chemodosimetric probe (1) is reported that selectively detects thiols over other relevant biological species by the turning on of its fluorescence through a Michael type reaction. The fluorogenic process upon its reaction was revealed to be mediated by intramolecular charge transfer, as confirmed by time-dependent density functional theory calculations. The application of probe 1 to cells is also examined by confocal microscopy, and its cysteine preference was observed by an ex vivo LC-MS analysis of the cellular metabolite.
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