4.8 Article

Highly Enantioselective One-Pot Synthesis of Spirocyclopentaneoxindoles Containing the Oxime Group by Organocatalyzed Michael Addition/ISOC/Fragmentation Sequence

Journal

ORGANIC LETTERS
Volume 13, Issue 23, Pages 6160-6163

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol2024955

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Funding

  1. National Natural Science Foundation of China [20962023, 21162034]
  2. Program for New Century Excellent Talents in University [NCET-10-0907]

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A highly diastereo- and enantioselective organocatalytic protocol for the synthesis of biologically Important spirocyclopentaneoxindoles containing the oxime functional group from easily accessible 3-allyl-substituted oxindoles and nitroolefins has been developed by a one-pot Michael addition/ISOC/fragmentation sequence.

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