Journal
ORGANIC LETTERS
Volume 13, Issue 9, Pages 2392-2394Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol200632d
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A simple, practical, and convenient fluorination of 1,3-dicarbonyl compounds was achieved by direct use of aqueous hydrofluoric acid and iodosylbenzene (PhIO). The reaction of ethyl benzoylacetate with the reagent system of aqueous HF and PhIO in CH2Cl2 gave ethyl 2-fluoro-2-benzolyacetate in 98% yield. Other 1,3-dicarbonyl compounds including beta-keto esters and 1,3-diketones underwent the fluorination reaction to give the corresponding fluorinated products in good yields.
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