4.8 Article

Enamine Carboxylates as Stereodetermining Intermediates in Prolinate Catalysis

Journal

ORGANIC LETTERS
Volume 13, Issue 20, Pages 5644-5647

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol2023533

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Funding

  1. EPSRC
  2. Scripps Research Institute
  3. Engineering and Physical Sciences Research Council [EP/G013470/1] Funding Source: researchfish
  4. EPSRC [EP/G013470/1] Funding Source: UKRI

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Experimental and computational studies probing the nature of Intermediates in the alpha-amination of aldehydes catalyzed by prolinate salts support an enamine carboxylate intermediate in the stereodetermining step.

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