Journal
ORGANIC LETTERS
Volume 13, Issue 19, Pages 5100-5103Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol201970m
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Funding
- Junta de Castilla y Leon [BU021A09, GR-172]
- Ministerio de Ciencia e Innovacion (MICINN)
- FEDER [CTQ2010-15358, CTQ2009-09949/BQU]
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An efficient synthesis of thiophenes and benzo[b]thiophenes has been developed from easily available bromoenynes and o-alkynylbromobenzene derivatives. This novel one-pot procedure involves a Pd-catalyzed C-S bond formation using a hydrogen sulfide surrogate followed by a heterocyclization reaction. Moreover, in situ functionalization with selected electrophiles further expands the potential of this methodology to the preparation of the corresponding highly substituted sulfur heterocycles.
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