4.8 Article

Nucleic Acid Templated Uncaging of Fluorophores Using Ru-Catalyzed Photoreduction with Visible Light

Journal

ORGANIC LETTERS
Volume 14, Issue 2, Pages 482-485

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol203029t

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Funding

  1. European Research Council (ERC) [201749]
  2. Institut Univervsitaire de France (IUF)
  3. European Research Council (ERC) [201749] Funding Source: European Research Council (ERC)

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Hybridization-based reactions have attracted significant attention. The nucleic acid templated photocatalyzed azide reduction using catalytic amounts of a [Ru(bpy)(2)phen](2+) conjugate is reported. The reaction could be performed with as little as 2% of the Ru nucleic acid probe and was shown to productively unquench 7-azido-coumarin as well as uncage a small molecule.

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