4.8 Article

Endo-Selective Enyne Ring-Closing Metathesis Promoted by Stereogenic-at-W Mono-Pyrrolide Complexes

Journal

ORGANIC LETTERS
Volume 13, Issue 4, Pages 784-787

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol1030525

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Funding

  1. National Institutes of Health [GM-59426]

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The utility of W-alkylidene complexes for enyne ring-closing metathesis is demonstrated in a direct comparison with Mo-based analogs. Tungsten complexes lead to less alkyne oligomerization and higher levels of endo-selectivity and enantioselectivity.

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