Journal
ORGANIC LETTERS
Volume 13, Issue 3, Pages 410-413Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol1027199
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- NIH [CA 052955]
- ARRA
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The histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) was used to turn on the biosynthesis of EGM-556, a new cyclodepsipeptide of hybrid biosynthetic origin, isolated from the Floridian marine sediment-derived fungus Microascus sp. The absolute configurations of three chiral centers were determined by Marfey's derivatization. EGM-556 represents one of the few examples in which silent biosynthetic genes, encoding a new secondary metabolite, were activated by means of epigenetic manipulation of the fungal metabolome.
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