Journal
ORGANIC LETTERS
Volume 13, Issue 7, Pages 1602-1605Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol200004s
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Funding
- Ministry of Science and Technology [2009ZX09501-00]
- Chinese Academy of Sciences
- National Natural Science Foundation of China [20632050, 20921091]
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Polysubstituted piperidines and tetrahydropyrans are synthesized from aldehydes and two classes of trisubstituted nitroolefins via an O-TMS protected diphenylprolinol catalyzed domino Michael addition/aminalization (or acetalization) process. This approach allows formation of four contiguous stereocenters in the piperidine or tetrahydropyran ring in one step with excellent enantioselectivity.
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