4.8 Article

An Unexpected Oxidation of Unactivated Methylene C-H Using DIB/TBHP Protocol

Journal

ORGANIC LETTERS
Volume 13, Issue 16, Pages 4308-4311

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol2016466

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Funding

  1. National University of Singapore [143-000-428-112]

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An in situ generated hypervalent iodine species, bis(tert-butylperoxy)iodobenzene, was used as a peroxy radical source for the oxidation of unreactive, remote, and isolated alkyl (cyclic or aliphatic) esters and amides to the corresponding keto compounds under very mild conditions.

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