Journal
ORGANIC LETTERS
Volume 13, Issue 19, Pages 5068-5071Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol2019295
Keywords
-
Categories
Funding
- JHU
Ask authors/readers for more resources
The selective alpha,alpha-difluorination of carbonyl compounds remains a challenge in modern organic synthesis; current methods often incorporate stepwise processes and/or harsh conditions, providing unsatisfactory mixtures of mono- and difluorinated products. In this communication, a practical, mild, and one-pot method for the selective alpha,alpha-difluorination of readily available acid chlorides is reported in which three separate catalysts act synergistically to form products in outstanding selectivity and fair to excellent yields.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available