4.8 Article

One-Pot Strategies for the Synthesis of the Tetrasaccharide Linkage Region of Proteoglycans

Journal

ORGANIC LETTERS
Volume 13, Issue 6, Pages 1506-1509

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol200192d

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Funding

  1. National Science Council [NSC 97-2113-M-001-033-MY3, NSC 98-2119-M-001-008-MY2, NSC 98-3112-B-007-005, NSC 98-2627-B-007-008]
  2. Academia Sinica

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A linker-attached tetrasaccharide corresponding to the linkage region of proteoglycans was synthesized via one-pot procedures from the silylated monosaccharide derivatives. Regioselective one-pot protection protocols were applied in generating the requisite monosaccharide building blocks whereas stereoselective one-pot glycosylation approaches were utilized to assemble the tetrasaccharide skeleton.

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