Journal
ORGANIC LETTERS
Volume 13, Issue 15, Pages 4056-4059Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol201566u
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Funding
- National Science Foundation [CHE-08-09659]
- Novartis
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [0809659] Funding Source: National Science Foundation
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A new two-step synthesis of highly substituted pyrrolidines has been developed. Chiral silane Lewis acid promoted enantioselective Mannich reactions of silyl ketene imines with acylhydrazones may be used to access bishomoallylic benzoic hydrazides that In turn may be cyclized to pyrrolidines by way of the thermal hydroamination reaction reported recently by Beauchemin. Importantly, excellent diastereoselectivity may be realized in the hydroamination reactions.
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