Journal
ORGANIC LETTERS
Volume 13, Issue 15, Pages 4060-4063Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol201567s
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- Pfizer Worldwide RD
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A new macrocyclization strategy to synthesize 12- to 31-membered 5-iodo-1,2,3-triazole-containing macrocycles is described. The macrocycles have been generated using a simple and efficient copper-catalyzed cycloaddition in flow under environmentally friendly conditions. This methodology also permits the facile, regioselective synthesis of 1,4,5-trisubstituted-1,2,3-triazole-containing macrocyles using palladium. catalyzed cross-coupling reactions.
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