4.8 Article

Nonmetal Catalyzed Insertion Reactions of Diazocarbonyls to Acid Derivatives in Fluorinated Alcohols

Journal

ORGANIC LETTERS
Volume 13, Issue 4, Pages 692-695

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol102923h

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Funding

  1. European Union (EU) within the EST network BIOMEDCHEM [MEST-CT-2005-020580]
  2. Region Ile-de-France

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The insertion reaction of diazocarbonyls to acids could be performed smoothly in fluorinated alcohols in the absence of metal catalyst. This new procedure allowed the chemoselective preparation of various functionalized compounds such as acyloxyesters, depsipeptides, and sulfonate, phosphonate, or boronate derivatives.

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