4.8 Article

Palladium-Catalyzed Carbonylative Reaction of 1-(2,2-Dibromovinyl)-2-alkenylbenzene and Carbon Monoxide, with Phenol or Alcohol

Journal

ORGANIC LETTERS
Volume 13, Issue 22, Pages 5980-5983

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol202420j

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Funding

  1. National Natural Science Foundation of China [21032007, 21172038]

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A palladium-catalyzed carbonylative reaction of 1-(2,2-dibromovinyl)-2-alkenylbenzene and carbon monoxide, with phenol or alcohol, is reported, which affords 1-methylene-1H-indene-2-carboxylates in moderate to good yields. This cascade process, which includes carbonylation and Heck reaction, proceeds smoothly with good functional group tolerance and high selectivity.

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