4.8 Article

Synthetic Studies on Indolocarbazoles: Total Synthesis of Staurosporine Aglycon

Journal

ORGANIC LETTERS
Volume 13, Issue 6, Pages 1418-1421

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol200094b

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Funding

  1. Department of Science and Technology (DST) New Delhi
  2. CSIR, New Delhi

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A synthesis of staurosporine aglycon and its analogs was achieved in a 28-36% overall yield starting from 2-methylindole. The prominent key steps for the synthesis of the Indolocarbazole alkaloids involved electrocyclization and nitrene insertion reactions.

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