Journal
ORGANIC LETTERS
Volume 13, Issue 7, Pages 1622-1625Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol200425c
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- Nanyang Technological University
- Singapore Ministry of Education [MOE2010-T2-1-009]
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Copper-catalyzed benzylic C-H oxygenation under an oxygen atmosphere was developed starting from carbonitriles and Grignard reagents via N-H imine intermediates. The present process is characterized by the following two-step sequence in a one-pot manner: (1) addition of Grignard reagents to carbonitriles to form N-H imines and (2) benzylic C-H oxygenation (C=O bond formation) triggered by 1,5-hydrogen atom transfer with transient iminyl copper species.
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