Journal
ORGANIC LETTERS
Volume 13, Issue 2, Pages 280-283Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol1026848
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- NIBR Education Office
- Global Discovery Chemistry (GDC)
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A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.
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