Journal
ORGANIC LETTERS
Volume 13, Issue 19, Pages 5180-5183Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol202052q
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- Novartis International AG
- Department of Chemistry, Massachusetts Institute of Technology
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General continuous-flow conditions for the Suzuki-Miyaura cross-coupling of heteroaryl halides and (hetero)arylboronic acids have been developed. A wide range of heterobiaryl products is obtained in excellent yields (20 examples) employing low catalyst loadings (0.05-1.5 mol % Pd).
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