Journal
ORGANIC LETTERS
Volume 13, Issue 10, Pages 2686-2689Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol200782d
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Funding
- ACS-PRF [DNI-5001400]
- NIGMS [RO1GM087581]
- NSF [DBI-0619576]
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A highly regioselective hydroformylation of allylic alcohols is reported toward the synthesis of p-hydroxy-acid and aldehyde products. The selectivity is achieved through the use of a ligand that reversibly binds to alcohols in situ, allowing for a directed hydroformylation to occur. The application to trisubstituted olefins was also demonstrated, which yields a single diastereomer product consistent with a stereospecific addition of CO and hydrogen.
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