Journal
ORGANIC LETTERS
Volume 13, Issue 16, Pages 4164-4167Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol2014335
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- Studienstiftung des deutschen Volkes
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We present a simple, mild, and highly effective method for the direct conversion of primary alcohols to carboxylic acids. TPAP serves as the catalyst, and NMO center dot H(2)O plays a dual role, acting as the co-oxidant and as a reagent for aldehyde hydrate stabilization. This previously unknown stabilizing effect of geminal diols by N-oxides is the key for the efficiency of the overall transformation.
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