Journal
ORGANIC LETTERS
Volume 13, Issue 13, Pages 3296-3299Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol200924e
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Funding
- Agence Nationale de la Recherche [ANR-07-CP2D-06]
- Universite Paul Cezanne
- CNRS
- Centre Regional de Competences en Modelisation Moleculaire de Marseille (CR-CMM)
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The secondary amido group of a-substituted beta-ketoamides plays a crucial role in the control of the reactivity and spatial arrangement (selectivity) in the organocatalyzed Michael addition to unsaturated carbonyls. This results in an unprecedented activation mode of substrates through H-bonding interactions allowing the construction of enantiomerically enriched functionalized all-carbon quaternary centers and spiroaminals of high synthetic potential.
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