4.8 Article

Total Synthesis of (±)-Kainic Acid: A Photochemical C-H Carbamoylation Approach

Journal

ORGANIC LETTERS
Volume 13, Issue 10, Pages 2674-2677

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol200772f

Keywords

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) [16790021, 22136006]
  2. Grants-in-Aid for Scientific Research [21590009, 16790021, 22136006] Funding Source: KAKEN

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A novel photochemical C-H carbamoylation of an octahydroisolndole derivative with PhNCO has allowed the authors to provide a unique access to a highly functionalized proline motif from which total synthesis of (+/-)-kainic acid, a bioactive marine alkaloid, has been accomplished.

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