Journal
ORGANIC LETTERS
Volume 13, Issue 18, Pages 4782-4785Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol201783d
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Funding
- Natural Science Foundation of China [30860342, 21162037, 81160384]
- Natural Science Foundation of Yunnan Province [2009CC017, 2008CD063]
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A concise and efficient route for the synthesis of highly substituted imidazopyrroloquinoline derivatives by simply refluxing a reaction mixture of different types of isatins and heterocyclic ketene aminals (HKAs) by acetic acid was developed. This method is suitable for combinatorial and parallel syntheses in drug discovery; consequently, a library of highly substituted imidazopyrroloquinoline derivatives was rapidly constructed using the present protocol.
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