Journal
ORGANIC LETTERS
Volume 13, Issue 10, Pages 2770-2773Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol200904v
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Funding
- Australian Postgraduate Award
- University of Queensland
- Australian Research Council, UQ [LP0989954]
- Institute for Molecular Bioscience
- Australian Research Council [LP0989954] Funding Source: Australian Research Council
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An Australian marine sediment-derived Isolate, Nocardiopsis sp. (CMB-M0232), yielded a new class of prenylated diketopiperazine, Indicative of the action of a uniquely regioselective diketopiperazine indole prenyltransferase. The bridged scaffold of nocardioazine A proved to be a noncytotoxic inhibitor of the membrane protein efflux pump P-glycoprotein, reversing doxorubicin resistance in a multidrug resistant colon cancer cell.
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