4.8 Article

An Efficient Route to Tetrahydroindeno[2,1-b]pyrroles via a Base-Promoted Reaction of (E)-2-Alkynylphenylchalcone with 2-Isocyanoacetate

Journal

ORGANIC LETTERS
Volume 13, Issue 24, Pages 6402-6405

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol202708f

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Funding

  1. National Natural Science Foundation of China [21032007, 21172038]

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A base-promoted cascade reaction of (E)-2-alkynylphenylchalcone with 2-isocyanoacetate provides a novel and efficient route for the synthesis of tetrahydroindeno[2,1-b]pyrroles. The reaction proceeds smoothly in air under mild conditions with high efficiency.

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