Journal
ORGANIC LETTERS
Volume 13, Issue 16, Pages 4268-4271Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol201616k
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Funding
- Natural Science and Engineering Research Council (NSERC) of Canada
- Fonds Quebecois pour la Recherche sur la Nature et les Technologies (FQRNT)
- Canadian Fund for Innovation
- Universite de Sherbrooke
- Boehringer Ingelheim
- FQRNT
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A new approach to the synthesis of quinolizidines involving a cascade of nucleophilic cyclizations triggered by chemoselective amide activation is reported. Particular attention was given to the effect of the nature of the tethered nucleophiles on the cascade of cyclizations. As a result, simple acyclic amides gave rapid access to functionalized quinolizidines bearing either a tertiary or quaternary center at the ring junction. Such a fused bicyclic motif is found in several alkaloids.
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