4.8 Article

Development of a Cholesterol-Conjugated Fluorescent Sensor for Site-Specific Detection of Zinc Ion at the Plasma Membrane

Journal

ORGANIC LETTERS
Volume 13, Issue 17, Pages 4558-4561

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol201746p

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Funding

  1. MEXT [70378850]
  2. Naito Foundation

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A cholesterol-conjugated fluorescence Zn2+ sensor based on the fluorescein platform was designed and synthesized. The cholesterol moiety is essential for localizing the Zn2+ sensor to the cell membrane, allowing the sensor to probe changes in the Zn2+ concentration in a localized area of the cell.

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