4.8 Article

Rh-Catalyzed Transannulation of N-Tosyl-1,2,3-Triazoles with Terminal Alkynes

Journal

ORGANIC LETTERS
Volume 13, Issue 14, Pages 3746-3749

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol2014347

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Funding

  1. National Institutes of Health [GM-64444]

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The first transannulation of 1,2,3-triazoles with terminal alkynes into pyrroles is reported. The reaction proceeds in the presence of a Rh(2)(oct)(4)/AgOCOCF(3) binary catalyst system providing a straightforward approach to 1,2,4-trisubstituted pyrroles In good to excellent yields.

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