Journal
ORGANIC LETTERS
Volume 13, Issue 8, Pages 2034-2037Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol200420u
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Funding
- NIH [U01 A1053877, GM086184]
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Lymphatic filariasis is caused by the parasitic nematodes Brugia malayi and Wuchereria bancrofti, and asparaginyl-tRNA synthetase (AsnRS) is considered an excellent antifilarial target. The discovery of three new tirandamycins (TAMs), TAM E (1), F (2), and G (3), along with TAM A (4) and B (5), from Streptomyces sp. 17944 was reported. Remarkably, 5 selectively inhibits the B. malayi AsnRS and efficiently kills the adult B. malayi parasite, representing a new lead scaffold to discover and develop antifilarial drugs.
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