Journal
ORGANIC LETTERS
Volume 13, Issue 5, Pages 1118-1121Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol103149b
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- U.S. National Institutes of Health [RR-16480, CA-135579]
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Privileged medicinal scaffolds based on the structures of tetra- and pentasubstituted 2-aminopyrroles were prepared via one-pot multicomponent reactions of structurally diverse aldehydes and N-(aryl-, hetaryl-, alkylsulfonamido)acetophenones with activated methylene compounds. This methodology was used in a four-step synthesis of alkaloids rigidins A, B, C, and Din overall yields of 61%, 58%, 60%, and 53%, respectively. Of these, rigidins B, C, and D were synthesized for the first time.
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