Journal
ORGANIC LETTERS
Volume 13, Issue 5, Pages 876-879Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol102933q
Keywords
-
Categories
Funding
- Nanyang Technological University
- Ministry of Education Academic Research Fund Tier 2 [T207B1220RS]
Ask authors/readers for more resources
A new class of chiral secondary amine organocatalyst was rationally designed as an efficient catalyst to catalyze the elusive Michael addition of aldehydes to vinyl sulfones. High yield and excellent enantioselectivities could be obtained at room temperature without having to resort to high catalyst loading, anhydrous solvents, and low temperatures. Efficient control of enamine conformation and face shielding as well as the rigid nature of the tricyclic skeleton, with an inherent chiral pocket, provide a well-organized chiral environment to effect this elusive reaction efficiently.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available