4.8 Article

Acid-Catalyzed Synthesis of Bicyclo[3.n.1]alkenediones

Journal

ORGANIC LETTERS
Volume 13, Issue 4, Pages 664-667

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol102909t

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Funding

  1. EPSRC
  2. EPSRC [EP/G007802/1] Funding Source: UKRI
  3. Engineering and Physical Sciences Research Council [EP/G007802/1] Funding Source: researchfish

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An acid-catalyzed Dieckmann-type reaction has been developed to access functionalized bicyclo[3.2.1]alkenediones. This methodology has been successfully extended to more substituted and larger ring homologues, providing a new and efficient route to the core of numerous attractive natural products and their analogues.

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