4.8 Article

Hyrtioseragamines A and B, New Alkaloids from the Sponge Hyrtios Species

Journal

ORGANIC LETTERS
Volume 13, Issue 4, Pages 628-631

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol102867x

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Funding

  1. Japan Society for the Promotion of Science
  2. Ministry of Education, Culture, Sports, Science, and Technology of Japan

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Two novel alkaloids with a furo[2,3-b]pyrazin-2(1H)-one moiety and a guanidino group, hyrtioseragamines A (1) and B (2), have been isolated from an Okinawan marine sponge Hyrtios species. The structures of 1 and 2 were elucidated on the basis of spectroscopic data and chemical conversions. Compounds 1 and 2 are the first natural products possessing a furo[2,3-b]pyrazine-related moiety.

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