Journal
ORGANIC LETTERS
Volume 13, Issue 2, Pages 320-323Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol1027927
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Funding
- Novartis Pharma AG
- Royal Society
- BP 1702 Fellowship
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A flow method for the synthesis of aliphatic and aromatic diazoketones from acyl chloride precursors has been developed and used to prepare quinoxalines in a multistep sequence without isolation of the potentially explosive diazoketone. The protocol showcases an efficient in-line purification using supported scavengers with time-saving and safety benefits and in particular a reduction in the operator's exposure to carcinogenic phenylenediamines.
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