Journal
ORGANIC LETTERS
Volume 13, Issue 12, Pages 3262-3265Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol201210t
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Funding
- National Institutes of Health (NIH) [GM 58160]
- Bristol-Myers Squibb
- NSF [CHE 9808061, DBI 9729592]
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A facile synthesis of unsymmetrical N,N'-diarylureas is described. The utilization of the Pd-catalyzed arylation of ureas enables the synthesis of an array of diarylureas in good to excellent yields from benzylurea via a one-pot arylation-deprotection protocol, followed by a second arylation.
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