4.8 Article

Synthesis of Unsymmetrical Diarylureas via Pd-Catalyzed C-N Cross-Coupling Reactions

Journal

ORGANIC LETTERS
Volume 13, Issue 12, Pages 3262-3265

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol201210t

Keywords

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Funding

  1. National Institutes of Health (NIH) [GM 58160]
  2. Bristol-Myers Squibb
  3. NSF [CHE 9808061, DBI 9729592]

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A facile synthesis of unsymmetrical N,N'-diarylureas is described. The utilization of the Pd-catalyzed arylation of ureas enables the synthesis of an array of diarylureas in good to excellent yields from benzylurea via a one-pot arylation-deprotection protocol, followed by a second arylation.

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