4.8 Article

Switching Regioselectivity in Crossed Acyloin Condensations between Aromatic Aldehydes and Acetaldehyde by Altering N-Heterocyclic Carbene Catalysts

Journal

ORGANIC LETTERS
Volume 13, Issue 5, Pages 880-883

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol102937w

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Funding

  1. NRF [R31-2008-000-10029-0, 2010-0023127, 2010-0022070, 2010-0029698]
  2. Sungkyunkwan University
  3. National Research Foundation of Korea [2010-0022070, 2010-0023127] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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An unprecedented high level of regioselectivities (up to 96%) in the intermolecular crossed acyloin condensations of various aromatic aldehydes with acetaldehyde was realized by an appropriate choice of N-heterocyclic carbene catalysts.

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