4.8 Article

Visualization of Nitroxyl in Living Cells by a Chelated Copper(II) Coumarin Complex

Journal

ORGANIC LETTERS
Volume 13, Issue 6, Pages 1290-1293

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol103077q

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Funding

  1. State Key Laboratory of Materials-Oriented Chemical Engineering [KL09-9]
  2. postgraduate practice innovation fund of Jiangsu province
  3. Nanjing University of Technology

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The coumarin-based probe Cu(II)-COT1 was successfully developed for the detection of HNO on the basis of the reduction reaction. In addition, highly selective turn on type fluorogenic behavior upon the addition of Angeli's salt (Na2N2O3) was also applied to bioimaging in A375 cells.

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