4.8 Article

A Concise Synthesis of Tetrabenazine: An Intramolecular Aza-Prins-Type Cyclization via Oxidative C-H Activation

Journal

ORGANIC LETTERS
Volume 13, Issue 24, Pages 6500-6503

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol202792q

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Funding

  1. Korea Institute of Science and Technology (KIST)
  2. National Research Foundation of Korea (NRF) [2010-0022531]
  3. National Research Foundation of Korea [2010-0022531] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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A concise synthesis of tetrabenazine and dihydrotetrabenazine is described. The key feature of this synthesis is the intramolecular aza-Prins-type cyclization of an amino allylsilane via oxidative C-H activation.

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