A Ferrocenyl-DHIPOH/Cu(OAc)2 Complex for Diastereo- and Enantioselective Catalysis of the 1,4-Addition of Glycine Derivatives to Alkylidene Malonates

A planar chiral ferrocene derivative Fc-DHIPOH served as an excellent N,O- chiral ligand for asymmetric copper catalyzed 1,4-addition of glycine derivatives to alkylidene malonates. The corresponding 1,4-adducts were obtained in high yields with excellent enantioselectivities up to 95% ee.