Journal
ORGANIC LETTERS
Volume 13, Issue 13, Pages 3518-3521Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol201329p
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Funding
- NIH, National Cancer Institute, Center for Cancer Research
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Extracts of the sponge genus Candidaspongia showed selective cytotoxicity toward melanoma cells in the NCI 60-cell-line screen. Continued investigation of the Candidaspongia sp. extracts led to the isolation of three new tedanolide analogues, precandidaspongiolides A (1) and B (2) and candidaspongiolide B (4), as well as candidaspongiolide A (3) and tedanolide (5). Semisynthetic derivatives were also generated to develop SAR. Candidaspongiolides A/B were the most potent and showed low nanomolar activity against several melanoma cell lines.
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