Journal
ORGANIC LETTERS
Volume 13, Issue 13, Pages 3498-3501Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol2012956
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Funding
- Japan Society for the Promotion of Science [23750171]
- Grants-in-Aid for Scientific Research [23550116, 23750171] Funding Source: KAKEN
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An asymmetric alpha-oxyamination could be successfully performed by a peptide catalyst and laccase. The combination of peptide catalysis and enzymatic air oxidation promoted the reaction smoothly in water without employing a metal reagent. The oxyaminated compounds could be obtained as both aldehyde and carboxylic acid products depending on the reaction conditions.
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