Journal
ORGANIC LETTERS
Volume 13, Issue 13, Pages 3450-3453Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol2011902
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Funding
- National Science Foundation [CHE-0809683]
- NSF/EPSCoR [EPS-0447479]
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Using a readily available secondary aminoalkyne as starting material, a powerful strategy was discovered to prepare precursors of biologically important unnatural cyclic aminoacids and fluorinated N-heterocycles with important ring sizes (e.g., 5-7) in a one-pot reaction using two nucleophilic additions in a tandem fashion.
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