4.8 Article

Synthesis of 2-(Polyfluoroaryl)benzofurans via a Copper(I)-Catalyzed Reaction of 2-(2,2-Dibromovinyl)phenol with Polyfluoroarene

Journal

ORGANIC LETTERS
Volume 14, Issue 1, Pages 70-73

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol202858f

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Funding

  1. National Natural Science Foundation of China [21032007, 21172038]
  2. Jiangxi Key Laboratory of Organic Chemistry, Jiangxi Science & Technology Normal University

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A novel and efficient route for the synthesis of 2-(polyfluoroaryl)benzofurans via a copper(I)-catalyzed tandem reaction of 2-(2,2-dibromovinyl)phenol with polyfluoroarene is reported. The corresponding products are generated in good yields. During the reaction process, a copper-catalyzed intramolecular C-O bond formation and a C-H activation are involved.

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