4.8 Article

Pyrophosphate-Selective Fluorescent Chemosensor Based on 1, 8-Naphthalimide-DPA-Zn(II) Complex and Its Application for Cell Imaging

Journal

ORGANIC LETTERS
Volume 13, Issue 19, Pages 5294-5297

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol202159x

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Funding

  1. CRI program [2011-0000420]
  2. Foundation of Ministry of Education of China
  3. Department of Science and Technology of Yunnan Province of China
  4. Ministry of Education, Science and Technology [NRF20110018396]

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A new zinc(II) complex with a two-dipicolylamine-substituted 1,8-naphthalimide for recognition of pyrophosphate with ratiometrical fluorescence changes in aqueous solution has been synthesized and characterized. Its biological application to monitor the intracellular pyrophosphate (PPi) was successfully demonstrated by the observation that the fluorescence of 1 was enhanced by the presence of the Zn(2+) ion and was quenched by addition of PPi.

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