Journal
ORGANIC LETTERS
Volume 13, Issue 9, Pages 2472-2475Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol200724q
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Funding
- National Natural Science Foundation of China [20802074]
- National Basic Research Program of China (973 Program) [2010CB833300]
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The first example of a direct catalytic asymmetric intermolecular aldol reaction of 3-isothiocyanato oxindoles to simple ketones with bifunctional thiourea-tertiary amine as catalyst is reported. This strategy provides a promising approach for the asymmetric synthesis of a range of enantioenriched spirocyclic oxindoles bearing two highly congested contiguous tetrasubstituted carbon stereocenters. Versatile transformations of the spirocyclic oxindole products into other structurally diverse spirocyclic oxindoles have also been demonstrated.
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