4.8 Article

Organocatalytic Asymmetric Intermolecular Dehydrogenative α-Alkylation of Aldehydes Using Molecular Oxygen as Oxidant

Journal

ORGANIC LETTERS
Volume 13, Issue 19, Pages 5212-5215

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol202090a

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Funding

  1. Peking University
  2. National Science Foundation of China [20872003]
  3. National Basic Research Program of China (973 Program) [2009CB825300]

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An organocatalytic enantioselective intermolecular oxidative dehydrogenative alpha-alkylation of aldehydes via benzylic C-H bond activation has been developed. The asymmetric reaction is smoothly fulfilled by using simple and green molecular oxygen as the oxidant. Two hydrogen dissociations make this transformation more environmentally benign because of high atom efficiency.

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