Journal
ORGANIC LETTERS
Volume 13, Issue 1, Pages 98-101Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol102626p
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Funding
- Fonds der Chemischen Industrie
- Deutsche Forschungsgemeinschaft (DFG)
- International NRW Graduate School of Chemistry
- Alexander von Humboldt Foundation
- Alfried Krupp von Bohlen and Halbach Foundation
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N-Heterocyclic carbene-catalyzed umpolung of aldehydes followed by their interception with diarylbromomethanes has been reported. This conceptually novel transition-metal-free cross-coupling of aldehydes with alkyl halides works well at low catalyst loadings and under mild reaction conditions leading to the formation of diaryl acetophenone derivatives in good yields. In addition, a-halo ketones and esters can also be used, as aldehyde reaction partners.
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