Journal
ORGANIC LETTERS
Volume 13, Issue 17, Pages 4664-4667Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol201877v
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Funding
- Council of Scientific and Industrial Research, New Delhi
- CAS Instrumentation Facility, Department of Chemistry, University of Calcutta
- UGC [37-398/2009 (SR)]
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This is the first report of an Innovative, one-pot, catalyst-free, pseudo-five-component synthesis of 1,2-dihydro[1,6]naphthyridines from methyl ketones, amines, and malononitrile In ecofriendly solvent water. The protocol avoids the use of expensive catalysts, toxic organic solvents and anhydrous condition. The approach to naphthyridines presented herein offers for the first time an unprecedented coupling which leads to the construction of both the nitrogen containing rings during the synthesis without starting from any nitrogen-containing heterocycle moiety.
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